个人简介
|
（可包含个人履历、学术任职与荣誉、科研项目、代表性成果等，500字左右，代表性项目和成果不计入总字数）
杨扬，博士，深圳市第三人民医院（国家感染性疾病临床医学研究中心）特聘研究员，南方科技大学研究生导师，主要从事病毒感染性疾病的致病机制和抗病毒药物研究，以第一作者和通讯作者（含共同）在JAMA、Nature Microbiology、Lancet Microbe、Nature Biomedical Engineering、Signal Transduction and Targeted Therapy、Nature Communications等杂志发表SCI论文65篇，总引用近7000次，H指数24；连续4年（2021-2024）入选全球前2%顶尖科学家榜单；担任hLife和iLABMED杂志青年编委，中华预防医学会生物安全分会、中国医院协会传染病医院分会委员、中国中西医结合学会传染病专业委员等协会委员。目前主持广东省杰出青年基金、国家自然科学基金面上项目、“十四五”科技重大专项等多个项目。相关研究成果获得广东省科技进步特等奖1项，深圳市科技进步二等奖1项。
代表性论文：
1. Jingjing Yang#, Wenjuan Li#, Zepeng Zhang#, Xiaohua Gong#,Xiaoyu Peng, Guosheng Hu, Xianglong Dai, Yaohui He, Ying Huang, Shiqiang Cao, Yang Yang*, Wen Liu*. Targeting PRMT7-mediated monomethylation of MAVS enhances antiviral innate immune responses and inhibits RNA virus replication. Proc Natl Acad Sci U S A. 2024 Nov 19;121(47):e2408117121. (IF: 9.4; JCR Q1; 中科院1区)
2. Min Wang#, Yuan Gao#, Chenguang Shen#, Wei Yang, Qi Peng, Jinlong Cheng, Han-Ming Shen, Yang Yang*, George Fu Gao*, Yi Shi*. A human monoclonal antibody targeting the monomeric N6 neuraminidase confers protection against avian H5N6 influenza virus infection. Nat Commun. 2024 Oct 14;15(1):7452. (IF: 14.7; JCR Q1; 中科院1区)
3. Zuning Ren#, Mengjun Li#, Jiayin Chen#, Xiaohua Gong#, Shuo Song, Delin li, Minghui Yang, Jianhai Yu, Sadia Asghar, Yanxin Cui, Shiyu Niu, Zhonghui Liao, Yushan Jiang, Jiahui Liu, Yuqing Li, Bao Zhang, Wei Zhao*, Jie Peng*, Yang Yang*, Chenguang Shen*. Identification of mpox M1R and B6R monoclonal and bispecific antibodies that efficiently neutralize authentic mpox virus. Emerg Microbes Infect. 2024 Dec;13(1):2401931. (IF: 8.4; JCR Q1; 中科院1区)
4. Shengjie Zhang†, Fuxiang Wang†, Yun Peng†, Xiaohua Gong, Guohao Fan, Yuanlong Lin, Liuqing Yang, Liang Shen, Shiyu Niu, Jiexiang Liu, Jing Yuan, Hongzhou Lu*, Yingxia Liu*, Yang Yang*. Evolutionary trajectory and characteristics of Mpox virus in 2023 based on a large-scale genomic surveillance in Shenzhen, China. Nat Commun. 2024 Aug 28;15(1):7452. (IF: 14.7; JCR Q1; 中科院1区)
5. Xiaohua Gong†, Ling Peng†, Fuxiang Wang†, Jiexiang Liu†, Yimin Tang, Yun Peng, Shiyu Niu, Juzhen Yin, Liping Guo, Hongzhou Lu*, Yingxia Liu*, Yang Yang*. Repeated Omicron infection dampens immune imprinting from previous vaccination and induces broad neutralizing antibodies against Omicron sub-variants. J Infect. 2024 Aug;89(2):106208. (IF: 28.2; JCR Q1; 中科院1区)
6. Yang Yang#*, Shiyu Niu#, Chenguang Shen#, Liuqing Yang#, Shuo Song#, Yun Peng, Yifan Xu, Liping Guo, Liang Shen, Zhonghui Liao, Jiexiang Liu, Shengjie Zhang, Yanxin Cui, Jiayin Chen, Si Chen, Ting Huang, Fuxiang Wang*, Hongzhou Lu*, Yingxia Liu*.Longitudinal viral shedding and antibody response characteristics of men with acute infection of monkeypox virus: a prospective cohort study. Nat Commun. 2024 May 27;15(1):4488. (IF: 14.7; JCR Q1; 中科院1区)
7. Yang Yang#*, Liping Guo#, Jing Yuan#, Zhixiang Xu, Yuchen Gu, Jiaqi Zhang, Yuan Guan, Jinhu Liang, Hongzhou Lu*, Yingxia Liu*. Viral and antibody dynamics of acute infection with SARS-CoV-2 omicron variant (B.1.1.529): a prospective cohort study from Shenzhen, China. Lancet Microbe. 2023 Aug;4(8):e632-e641. (IF: 38.1; JCR Q1; 中科院1区)
8. Ying Liu#, Yang Yang#, Guanghui Wang#, Dou Wang#, Pan-Lin Shao, Jiahu Tang, Tingzhen He, Jintao Zheng, Ruibin Hu, Yiyi Liu, Ziyi Xu, Dan Niu, Jiahui Lv, Jingkai Yang , Hongjun Xiao, Shuai Wu, Shuang He, Zhongrong Tang, Yan Liu, Meijie Tang*, Xingyu Jiang*, Jing Yuan*, Hongjie Dai*, Bo Zhang*. Multiplexed discrimination of SARS-CoV-2 variants via plasmonic-enhanced fluorescence in a portable and automated device. Nat Biomed Eng. 2023 Dec;7(12):1636-1648. (IF: 29.2; JCR Q1; 中科院1区)
9. Yang Yang#, Minghui Yang#, Yun Peng#, Yanhua Liang#, Jinli Wei, Li Xing, Liping Guo, Xiaohe Li, Jie Li, Jun Wang, Mianhuan Li, Zhixiang Xu, Mingxia Zhang, Fuxiang Wang, Yi Shi, Jing Yuan*, Yingxia Liu*. Longitudinal analysis of antibody dynamics in COVID-19 convalescents reveals neutralizing responses up to 16 months after infection. Nat Microbiol. 2022 Mar;7(3):423-433. (IF: 30.9; JCR Q1; 中科院1区)
10. Yang Yang#*, Xiaohua Gong#, Jun Wang#, Shisong Fang, Jiaqi Zhang, Xuejiao Liao, Yuan Guan, Weihua Wu, Yingxia liu*, Hongzhou Lu*. Comparative neutralization profiles of naive and breakthrough infections with Delta, Omicron BA.1 and BA.2 variants of SARS-CoV-2. Signal Transduct Target Ther. 2022 Sep 9;7(1):316. (IF: 38.1; JCR Q1; 中科院1区)
11. Ruibin Hu#, Yang Yang#, Ying Liu, Tao Liao, Yiyi Liu, Jiahu Tang, Guanghui Wang, Guoxin Wang, Yongye Liang, Jing Yuan*, Bo Zhang*. Multiplexed evaluation of immunity against SARS-CoV-2 variants using surface enhanced fluorescence from a nanostructured plasmonic chip. J Nanobiotechnology. 2022 Dec 15;20(1):533. (IF: 9.4; JCR Q1; 中科院1区)
12. Yang Yang#, Chenguang Shen#, Jinxiu Li#, Jing Yuan, Jinli Wei, Fengmin Huang, Fuxiang Wang, Guobao Li, Yanjie Li, Li Xing, Ling Peng, Minghui Yang, Mengli Cao, Haixia Zheng, Weibo Wu, Rongrong Zou, Delin Li, Zhixiang Xu, Haiyan Wang, Mingxia Zhang, Zheng Zhang, George F. Gao, Chengyu Jiang*, Lei Liu*, Yingxia Liu*. Plasma IP-10 and MCP-3 levels are highly associated with disease severity and predict the progression of COVID-19. J Allergy Clin Immunol, 2020 Jul;146(1):119-127.e4. (IF: 14.2; JCR Q1; 中科院1区)
13. Yang Yang#, Minghui Yang#, Jing Yuan#, Fuxiang Wang#, Zhaoqin Wang, Jinxiu Li, Mingxia Zhang, Li Xing, Jinli Wei, Ling Peng, Gary Wong, Haixia Zheng, Weibo Wu, Chenguang Shen, Mingfeng Liao, Kai Feng, Jianming Li, Qianting Yang, Juanjuan Zhao, Lei Liu*, Yingxia Liu*. Laboratory Diagnosis and Monitoring the Viral Shedding of SARS-CoV-2 Infection. The Innovation, 2020 Nov 25;1(3):100061. (IF: 32.1; JCR Q1; 中科院1区)
14. Fang Zhao#, Yang Yang#, Zhaoqin Wang#, Liang Li*, Lei Liu*, Yingxia Liu*. The Time Sequences of Respiratory and Rectal Viral Shedding in Patients With Coronavirus Disease 2019. Gastroenterology. 2020 Sep;159(3):1158-1160.e2. (IF: 33.8; JCR Q1; 中科院1区)
15. Chenguang Shen#, Zhaoqin Wang#, Fang Zhao#, Yang Yang#, Jinxiu Li, Jing Yuan, Fuxiang Wang, Delin Li, Minghui Yang, Li Xing, Jinli Wei, Haixia Xiao, Yan Yang, Jiuxin Qu, Ling Qing, Li Chen, Zhixiang Xu, Ling Peng, Yanjie Li, Haixia Zheng, Feng Chen, Kun Huang, Yujing Jiang, Dongjing Liu, Zheng Zhang*, Yingxia Liu*, Lei Liu*. Treatment of 5 critically ill patients with COVID-19 with convalescent plasma. JAMA, 2020 Apr 28;323(16):1582-1589. (IF: 157.3; JCR Q1; 中科院1区)
代表性课题：
1. 广东省自然科学基金杰出青年项目：重大病毒性传染病的诊治和致病机制研 究，课题负责人，资助金额100万，在研。
2. 国家自然科学基金面上项目：新型冠状病毒N蛋白通过ZBP1-RIPK3通路激活坏死性凋亡诱导宿主炎症反应的分子机制（82371783），课题负责人，资助金额50万，在研。
3. 国家自然科学基金面上项目：新型冠状病毒灭活疫苗诱导的免疫选择压力下介导免疫逃逸关键位点的前瞻性筛选（32170936），课题负责人，资助金额58万，在研。
4. 国家重点研发计划：X病原体和超级细菌的智能甄别及医防联合监测预警技术体系研究（2024YFC2309903），子课题负责人，资助金额153万，在研。
|
